W. Darlene Reid, BMR, PhD

Professor, Department of Physical Therapy
Department of Physical Therapy
160-500 University Avenue
Toronto, Ontario, M5G 1V7

Email:  darlene.reid@utoronto.ca
Phone:
416-978-0301
Lab:      416-946-5672
Lab:      Rehabilitation Aimed at Muscle Performance (RAMP)

Darlene Reid obtained her Bachelor of Medical Rehabilitation (PT) from the University of Manitoba in 1979 and her PhD from the University of British Columbia in 1988. Darlene was a Professor in the Department of Physical Therapy at the University of British Columbia and chaired the Research Graduate Programs in Rehabilitation Sciences where she guided considerable expansion of the program. In the fall of 2014, she was recruited to the University of Toronto to be Chair of the Department of Physical Therapy from January 2015 to December 2018.  She is currently fully engaged in her research program and teaching research design to graduate students.

Dr. Reid’s involvement in organizations at the national level has furthered the development and interdisciplinary collaboration of cardiopulmonary physical therapy, including: Co-Chair of the Scientific Program of the Canadian Respiratory Conference; the Canadian Physiotherapy Cardiorespiratory Society of the Lung Association; Cardiorespiratory Division of the Canadian Physiotherapy Association; the Canadian Thoracic Society COPD Guidelines Committee on Exercise; Canadian Thoracic Society–COPD Guidelines–National Implementation and Dissemination Committee. Dr.Reid has received recognition awards for leadership from the National Lung Association, a Killam Research Fellowship, a Physiotherapy Association of British Columbia Research Award, and a Silver Quill Award for Outstanding Knowledge Translation article in the Physiotherapy Canada journal.

last five years.  Trainees are underlined

Hassan SA, Campos M, Kasawara KT, Bonetti LV, Fregonezi GAF, Stanbrook MB Reid WD. Changes in oxyhemoglobin concentration in the prefrontal cortex during cognitive-motor dual tasks in people with chronic obstructive pulmonary disease.   06 May 2020 COPD: Journal of Chronic obstructive pulmonary disease. Online DOI: 10.1080/15412555.2020.1767561

Nell HJ, Castelli LM, Bertani D, Jipson AA, Meagher SF, Melo LT, Zabjek K, Reid WD.The effects of hypoxia on muscle deoxygenation and recruitment in the flexor digitorum superficialis during submaximal intermittent handgrip exercise. BMC Sports Science, Medicine and Rehabilitation DOI: 10.1186/s13102-020-00163-2.  Accepted 18Jan2020. On line May 15 2020 .

Sklar MC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Rittayamai N, Harhay MO, Reid WD, Tomlinson G, Rozenberg D, McClelland W, Riegler S, Slutsky AS, Brochard L, Ferguson ND, and Goligher EC. Association of low baseline diaphragm muscle mass with prolonged mechanical ventilation and mortality among critically ill patients. JAMA Network Open. 2020;3(2):e1921520. pp1-14 doi:10.1001/jamanetworkopen.2019.21520  Feb 19 2020 

Derbakova A, Khu S, Ho K, Lewis C, Ma T, Melo LT, Zabjek KF, Goligher E, Brochard L, Fregonezi G, Reid WD. Recruitment of primary and accessory muscles of inspiration during submaximal inspiratory threshold loading versus repetitive neck flexion in healthy participants.  Med Sciences Sports Ex Jan16 2020; 52(7); doi: 10.1249/MSS.0000000000002271..

Hanada M, Kasawara KT, Mathur S, Rozenberg D, Kozu R, Hassan SA, Reid WD.  Aerobic and breathing exercises improve dyspnea, exercise capacity and quality of life in idiopathic pulmonary fibrosis patients: systematic review and meta-analysis. J Thoracic Dis. 2020 Mar; 12(3):1041-1055; 12.27:1-16 doi: 10.21037/jtd.2019.12.27  .

Wickerson L, Mathur S, Brooks D, Bonetti L, Singer L, Granton J, Reid WD. Skeletal muscle oxygenation and regional blood volume during incremental limb loading in interstitial lung disease. ERJ Open Res 2020; 6: 00083-2019 [https://doi.org/10.1183/23120541.00083-2019].

Pazzianotto-Forti EM, Moreno MA, Plater E, Baruki SBS, Rasera Junior I, Reid WD. Impact of Physical Training Programs on Physical Fitness in Class II and III Obese Subjects: A Systematic Review and Meta-Analysis. Physical Therapy Journal.  Accepted Nov 20 2019.  Published online Mar 25 2020 https://doi.org/10.1093/ptj/pzaa045

Rozenberg D, Sitzer N, Porter S, Weiss A, Colman R, Reid WD, Shapera S, Fisher, J, Wentlandt K. Idiopathic Pulmonary Fibrosis: A review of disease, pharmacological and non-pharmacological strategies with a focus on symptoms, function, and health-related quality of life. J Pain Symptom Management JPS10346  Online Dec 28 2019.  In press, journal pre-proof https://doi.org/10.1016/j.jpainsymman.2019.12.364

Lima I, Sarmento A, Goes MC, Mazzuca E, LoMauro A, Reid WD, Aliverti A, Fregonezi GA. After-effects of thixotropic maneuvers on chest wall and compartmental operational volumes of healthy subjects using optoelectronic plethysmography Front. Physiol., Nov 2019; 10 (1376):1-10 | https://doi.org/10.3389/fphys.2019.01376

Bonetti LV, Hassan SA, Kasawara KT, Reid WD. The effect of working memory task on spatiotemporal gait parameters in healthy younger and middle-and-older subjects during dual-tasking. Exp Brain Research 2019: 237:3123–3132.  https://doi.org/10.1007/s00221-019-05659-z  Accepted Sep 20 2019 .

Chen Y-W, Ramsook AH, Coxson HO, Bon J, Reid WD.  Prevalence and risk factors for osteoporosis in individuals with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Chest. Dec 2019;156(6)1092-1110. https://doi.org/10.1016/j.chest.2019.06.036 .

Wickerson L, Brooks D, Granton J, Reid WD, Rozenberg D, Singer L, Mathur S. Feasibility of interval aerobic exercise in individuals with advanced interstitial lung disease: a feasibility study. Physiotherapy Theory and Practice 2019; 1-9. Published online Oct 18 2019 at https://doi.org/10.1080/09593985.2019.1678207 

Shah N, Melo L, Reid WD, Cioffi I.  Masseter deoxygenation in adults at risk for temporomandibular disorders. J Dent Res. 2019 Jun; 98 (6):666-672 ; https://doi.org/10.1177/0022034519837249.

Hanada M, Soyama A, Hidaka M, Nagura H, Oikawa M, Tsuji A, Kasawara KT, Mathur S, Reid WD, Takatsuki M, Eguchi S and Kozu R . Effects of quadriceps muscle neuromuscular electrical stimulation in living donor liver transplant recipients: Phase II single blinded randomized controlled trial.  Clin Rehab 2019; 33(5):875-884 https://doi.org/10.1177/0269215518821718 

Bonetti LV, Hassan SA, Lau S-T, Melo LT, Patterson K, Reid WD. Oxyhemoglobin changes in the prefrontal cortex in response to cognitive tasks: a systematic review. International Journal of Neuroscience (INES). 2019;129:2, 194-202,https://doi.org/10.1080/00207454.2018.1518906 .  .

Goligher EC, Brochard,LJ,  Reid WD, Fan E, Slutsky AS, Herridge MS, Kavanagh BP, Rubenfeld GD, Ferguson ND. Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure.  Lancet Respiratory Medicine.  2019; 7(1)90-98.  https://doi.org/10.1016/S2213-2600(18)30366-7 

Kasawara K, Minana M, Hanada M, Reid WD.  Pathophysiology of muscle in pulmonary and cardiovascular conditions.  Cardiopulmonary Physical Therapy Journal, Special Issue.  2019 Jan; 30(1):5-14. Published online https://journals.lww.com/cptj/Abstract/publishahead/Pathophysiology_of_Muscle_in_Pulmonary_and.99973.aspx. doi: 10.1097/CPT.0000000000000096 .

Sima CA, van Eeden SF, Reid WD, Sheel AW, Benari O, Kirkham AR, Camp PG. The relationship between resting heart rate and arterial stiffness in patients with chronic obstructive pulmonary disease: implications for pulmonary rehabilitation. Canadian Journal of Respiratory, Critical Care and Sleep Medicine. Apr 2019 :1-8. https://doi.org/10.1080/24745332.2019.1596772.

Francisco C, Bhatawadekar SA, Babineaur J, Reid WD, Yadollahi A.  Effects of physical exercise training on nocturnal symptoms in asthma: systematic review.  PLOS ONE 13(10): e0204953.  Published October 22 2018. https://doi.org/10.1371/journal.pone.0204953 

Cabral EEA, Fregonezi GAF, Basoudan N, Melo L, Mathur S, Reid WD. Surface electromyography (sEMG) of extradiaphragm respiratory muscles in healthy subjects: a systematic review.  Journal of Kinesiology and Electromyography 2018; 42:123-135.  Accepted July 17, 2018.  Access at https://doi.org/10.1016/j.jelekin.2018.07.004 .

Pazzianotto-Forti EM, Sgariboldi D, Rasera Junior I, Reid WD. Impact of pain in overweight to morbidly obese women: a cross sectional study- preliminary findings.  Physiotherapy.  2018; 104(4):417-423 https://doi.org/10.1016/j.physio.2018.05.004.  Co-.

Chen Y-W, Coxson H, Coupal T, Lam S, Munk P, Leipsic J, Reid WD. The contribution of thoracic vertebral deformity and arthropathy to trunk pain in patients with chronic obstructive pulmonary disease (COPD).  Respir Med 2018; 137:115-122. Accepted March 2, 2018  .

Sima CA, Lau BC, Taylor CM, van Eeden SF, Reid WD, Sheel AW, Kirkham AR, Camp PG. (2016). Myocardial infarction injury in chronic lung disease patients undergoing pulmonary rehabilitation: frequency and association with heart rate parameters. Physical Medicine and Rehabilitation 2018; 10(9):917-925.
https://doi.org/10.1016/j.pmrj.2018.03.005

Vorona S, Sabatini U, Al-Maqbali S, Dres M, Bissett B, Van Haren F, Martin AD, Urrea C, Brace D, Parotto M, Herridge MS, Adhikari NKJ, Fan E, Melo LT, Reid WD, Brochard LJ, Ferguso ND, Goligher EC. Inspiratory muscle rehabilitation in critically ill adults: a systematic review & meta-analysis.  Annals of the American Thoracic Society. 2018; 15(6):735-744. https://doi.org/10.1513/AnnalsATS.201712-961OC       PubMed: 29584447

Shadgan B, Pakravan A, Hoens A, Reid WD. The effects of contrast baths application on intramuscular hemodynamics and oxygenation, as monitored by near infrared spectroscopy. Journal of Athletic Training 2018;53(8):782-787. https://doi.org/10.4085/1062-6050-127-17 .

Chen Y-W, Camp PG, Coxson HO, Road JD, Guenette JA, Hunt MA, Reid WD. A comparison of pain, fatigue, dyspnea and their impact on quality of life in pulmonary rehabilitation participants with chronic obstructive pulmonary disease.  Published online Dec 11 2017.  J COPD 2018; 15(1):65-72. https://doi.org/10.1080/15412555.2017.1401990  .

Wickerson L, Brooks D , Reid WD, Singer LG, Granton J, Mathur S. Exertional oxygen requirements during exercise training in advanced interstitial lung disease.  J Cardiopulmonary Rehabilitation and Prevention. DOI: 10.1097/HCR.0000000000000338 PMID: 29952810  2018; 38(6):419-424  

Tanaka T, Basoudan N, Melo LT, Wickerson L, Brochard LJ, Goligher EC, Reid WD.  Deoxygenation of inspiratory muscles during cycling, hyperpnoea and loaded breathing in health and disease: a systematic review.  Clin Physiol Funct Imaging 2018;38:554–565. DOI 10.1111/cpf.12473 

Goligher EC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Vorona S, Sklar MC, Rittayamai N, Lanys A, Murray A, Brace D, Urrea C, Reid WD, Tomlinson G, Slutsky AS, Kavanagh BP, Brochard LJ, Ferguson ND. Mechanical ventilation-induced diaphragm atrophy strongly impacts clinical outcomes. Am J Respir Crit Care Med. 2018 Jan 15;197(2):204-213. doi: 10.1164/rccm.201703-0536OC.

Sima CA, Inskip JA, Sheel AW, van Eeden SF, Reid, WD, Camp PG (2017).  The reliability of short-term measurement of heart rate variability during spontaneous breathing in people with chronic obstructive pulmonary disease. Revista Portuguesa de Pneumologia 2017; 23(6):338-342.

Ramsook AH, Molgat-Seon Y, Schaeffer MR, Wilkie SS Camp PG, Reid WD, Romer LM, Jordan A. Guenette JA.  Effects of inspiratory muscle training on respiratory muscle electromyography and dyspnoea during exercise in healthy men.  J Appl Physiol 2017;122(5):1267-1275. doi: 10.1152/japplphysiol.00046.2017. Epub 2017 Mar 2.  or Collaborator.

Chen Y-W, Camp PG, Coxson HO, Road JD, Guenette JA, Hunt MA, Reid WD.  Comorbidities that cause pain and the contributors to pain in individuals with chronic obstructive pulmonary disease.  Arch Phys Med Rehab 2017; 98(8):1535-1543. DOI 10.1016/j.apmr.2016.10.016 .

Kubas C, Chen Y-W, Echeverri S, Greenway C, McCann S, Kennedy C, Reid WD. Reliability and validity of cervical range of motion and muscle strength testing. JSCR-08-6048R3.  Journal of Strength & Conditioning Research. Apr 2017; 31(4):1087-1096. doi: 10.1519/JSC.0000000000001578. .

Chen Y-W, Coxson H, Reid WD. Reliability and validity of the brief fatigue inventory and dyspnea inventory in people with chronic obstructive pulmonary disease. Journal of Pain and Symptom Management. 2016 Mar 1. 52(2):298-304. . http://dx.doi.org/10.1016/j.jpainsymman.2016.02.018

Basoudan N, Shadgan B, Guenette JA, Road J, Reid WD. Effect of acute hypoxia on inspiratory muscle oxygenation during incremental inspiratory loading in healthy adults. Eur J Appl Physiol. 2016; 116:841-850. .

Sima C, Sheel A W, van Eeden S F, Reid W D, Taylor C M, Camp P G. Pulse wave velocity measurements in moderate to severe chronic obstructive pulmonary disease: A test-retest reliability study. International Journal of Cardiology. 2016 Jan 15;203:301-2.  or Collaborator.

Reid WD, Sheel AW, Shadgan B, Garland SJ, Road JD. Recruitment and deoxygenation of sternocleidomastoid and biceps during incremental loading in stable COPD patients. Journal of Cardiopulmonary Rehabilitation and Prevention. 2016; 36:279-287.  Principal Author

Sales A, Guilherme A, Ramsook A, Guenette J, Lima I, Reid WD. Respiratory muscle endurance after training in athletes and non-athletes: a systematic review and meta-analysis. Physical Therapy in Sport. 2016;17:76-86. Available from: http://www.physicaltherapyinsport.com/article/S1466-853X(15)00065-6/pdf. .

Chen Y-W, Hunt MA, Campbell KL, Peill K, Reid WD. The effect of Tai Chi on four chronic conditions - cancer, osteoarthritis, heart failure and chronic obstructive pulmonary disease: a systematic review and meta-analyses. Br J Sports Med. 2015 Sep 17:1-12. Available from: http://bjsm.bmj.com/content/early/2015/09/04/bjsports-2014-094388.abstract. .

Shadgan B, Pereira G, Menon M, Jafari S, Reid WD, O’Brien JP. Risk factors for acute compartment syndrome of the leg associated with tibial diaphyseal fractures in adults. Journal of Orthopaedics and Traumatology. 2015 Sep 1;16(3):185-192. Published online December 28, 2014. Available from: http://link.springer.com/article/10.1007%2Fs10195-014-0330-y. .

Shadgan B, Med S, Pakravan AH, Hoens A, Reid WD. Subcutaneous and Intramuscular Hemodynamics and Oxygenation After Cold-Spray Application as Monitored by Near-Infrared Spectroscopy. J Athl Train. 2015 Jun 22;50(8):800-805. .

Miller RR, Reid WD, Mattman A, Yamabayashi C, Steiner T, Parker S, Gardy J, Tang P, Patrick DM. Submaximal exercise testing with near-infrared spectroscopy in myalgic encephalomyelitis/chronic fatigue syndrome patients compared to healthy controls: a case-control study. J Transl Med. 2015 May 20;13:159.

Camp PG, Reid WD, Chung F, Kirkham A, Brooks D, Goodridge D, Marciniuk DD, Hoens AM. Clinical decision-making tool for safe and effective prescription of exercise in acute exacerbations of chronic obstructive pulmonary disease: results from an interdisciplinary delphi survey and focus groups. Phys Ther. 2015 Apr 16;95(10):1387-1396. .

Patrick DM, Miller RR, Gardy JL, Parker SM, Morshed MG Steiner TS, Singer J Shojania K Tang P, Complex Chronic Disease Study Group - A MattmanS SirrsWD ReidP PhillipsA Avina-ZubietaJ ReynoldsH WongA BestedI HyamsB NgG BlaneyJ SpinelliJ Isaac-RentonL HoangM KrajdenM McCabe Lyme Disease Diagnosed by Alternative Methods: A Phenotype Similar to That of Chronic Fatigue Syndrome. Clin Infect Dis. 2015;61(7):1084‐1091. doi:10.1093/cid/civ470

See more publications by Darlene Reid on PubMed.

Professor Reid is a clinical scientist whose investigations have spanned basic sciences, clinical, and translational research. Research themes have focused on dysfunction of the inspiratory and limb muscles in chronic disease that involves quantification of muscle structure and function at the cellular and macroscopic level. Recent work has focused on muscle performance in chronic disease and the experience of pain in people living with COPD. Dr. Reid has also directed her current research towards using non-invasive tools that can be taken to the bedside including wireless near infrared spectroscopy, dynamometry, and inclinometry. She has forged research collaborations nationally and internationally including Europe, Japan, and Brazil. Dr. Reid supervises research trainees at the MSc, PhD and PDF level in Rehabilitation Sciences and is also interested in collaborating with visiting research scientists.

Dr. Reid is active in knowledge translation endeavours that include the development of systematic reviews and clinical practice guidelines in addition to implementation strategies.

Recent and Ongoing Research

For more information about previous research, please see links above, contact Dr. Reid and review publications listed under the Publications tab.

Dr. Reid’s teaching has focused on cardiopulmonary physiotherapy and research design. Dr. Reid was the senior editor of the recently released second edition of the textbook Cardiopulmonary Physical Therapy: Management and Case Studies that provides an interactive, learning approach that combines: clinical notes on assessment and management; twenty-four cases that show typical presentations of common pulmonary, cardiac and neuro conditions; and answer guides for questions posed in the assessment and management chapters and for the twenty-four cases.