Reconstruction of 3D images from MRIs in order to evaluate regional thigh muscle atrophy in people with chronic obstructive pulmonary disease (COPD)

Details on this research can be found HajGhanbari et al.  3D shape analysis of thigh muscles: People with chronic obstructive pulmonary disease versus healthy older adults.   Academic Radiology Feb 2011;18(2):155-66.  http://dx.doi.org/10.1016/j.acra.2010.09.008

  • We examined regional changes in volume and shape of the thigh muscles because these muscles differ in architecture and function.
  • Compared to healthy people, vastus intermedius and semimembranosus showed the most shape abnormalities in the COPD group.
  • More shape anomalies were found in the middle to proximal regions of all knee extensor muscles in people with COPD.
  • More abnormalities of shape were found in the knee extensors than in the knee flexors of people with COPD

Future investigations are required to explore why these regional shape changes occur and how to design specific exercises and other interventions to reverse these changes.

3D image from MRI showing leg structure

3D image from MRI featuring close-up on thigh