Near infrared spectroscopy (NIRS) performed during ankle fracture repair

Details on this research can be found at Shadgan B, et al. Hemodynamic and oxidative mechanisms of tourniquet-induced muscle injury:  near-infrared spectroscopy for the orthopedic setting.  Journal of Biomedical Optics.  17, 081408 (2012), DOI:10.1117/1.JBO.17.8.081408 PMID:23224169.

  • Leg with sensors during surgerya thigh tourniquet was inflated on the injured limb (300 mmHg).
  • Leg muscle biopsies were collected before and after tourniquet inflation
  • Average ischemia duration was 43.2±14.6  min
  • The decrease in oxygenated and total hemoglobin was associated with higher levels of protein oxidation, a measure of muscle injury.
  • These data indicate that using CW NIRS, it is possible to predict orthopedic tourniquet-associated muscle oxidative injury noninvasively.

Graph showing concentration changes during leg surgery